For research use only. Not for therapeutic Use.
AOH1160 is a potent oral small molecule proliferating cell nuclear antigen (PCNA) inhibitor that interferes with DNA replication, blocks homologous recombination-mediated DNA repair, leads to cell cycle arrest and induces apoptosis[1].
AOH1160 (500 nM, 48 h) can lead to tumor cell cycle arrest and induce tumor cell apoptosis[1].
AOH1160 (40 mg/kg, gavage once a day) can inhibit the growth of breast cancer and small cell lung cancer in mice[1].
| Catalog Number | I018151 |
| CAS Number | 2089314-57-6 |
| Synonyms | N-[2-oxo-2-(2-phenoxyanilino)ethyl]naphthalene-1-carboxamide |
| Molecular Formula | C25H20N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H20N2O3/c28-24(17-26-25(29)21-14-8-10-18-9-4-5-13-20(18)21)27-22-15-6-7-16-23(22)30-19-11-2-1-3-12-19/h1-16H,17H2,(H,26,29)(H,27,28) |
| InChIKey | COPRLRLXDBSLET-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)OC2=CC=CC=C2NC(=O)CNC(=O)C3=CC=CC4=CC=CC=C43 |
| Reference | [1]. Gu L, et al. The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA. Clin Cancer Res. 2018 Dec 1;24(23):6053-6065. |
