AP1867-2-(carboxymethoxy)

• CAT Number: I017979
• CAS Number: 2230613-03-1
• Molecular Formula: C₃₈H₄₇NO₁₁
• Molecular Weight: 693.78
• Purity: ≥95%
• Target: Immunology/Inflammation
• IUPAC Name: 2-[2-[(1R)-3-(3,4-dimethoxyphenyl)-1-[(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid
• InChI: InChI=1S/C38H47NO11/c1-7-26(25-21-33(46-4)36(48-6)34(22-25)47-5)37(42)39-19-11-10-13-28(39)38(43)50-30(27-12-8-9-14-29(27)49-23-35(40)41)17-15-24-16-18-31(44-2)32(20-24)45-3/h8-9,12,14,16,18,20-22,26,28,30H,7,10-11,13,15,17,19,23H2,1-6H3,(H,40,41)/t26-,28-,30+/m0/s1
• InChIKey: UYXSZUBFOQLRNQ-BTIIJPOSSA-N
• SMILES: CC[C@@H](C1=CC(=C(C(=C1)OC)OC)OC)C(=O)N2CCCC[C@H]2C(=O)O[C@H](CCC3=CC(=C(C=C3)OC)OC)C4=CC=CC=C4OCC(=O)O

AP1867-2-(carboxymethoxy) (Cat.No:I017979), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules. dTAG molecules engage FKBP12F36V and CRBN. It contains a carboxymethoxy functional group, which enhances its reactivity and solubility in various solvents, making it useful in organic synthesis and pharmaceutical applications. This compound is typically employed in the creation of complex molecules for drug discovery, as well as in the formulation of coatings or additives. Its unique properties allow it to serve in diverse applications requiring precise molecular interactions and modifications.

Reference

[1]. Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441.