Apatinib (YN968D1) mesylate

• CAT Number: I002552
• CAS Number: 1218779-75-9
• Molecular Formula: C25H27N5O4S
• Molecular Weight: 493.58
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: C[S](O)(=O)=O.O=C(NC1=CC=C(C=C1)C2(CCCC2)C#N)C3=CC=CN=C3NCC4=CC=NC=C4

Apatinib mesylate (YN968D1, Rivoceranib) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib mesylate induces both autophagy and apoptosis.

Reference

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[2] Mi YJ, et al. Cancer Res, 2010, 70(20), 7981-7991.
[3] Tong XZ, et al. Biochem Pharmacol, 2012, 83(5), 586-597.