For research use only. Not for therapeutic Use.
APE1-IN-1（Cat No.:I042934）is a potent inhibitor targeting apurinic/apyrimidinic endonuclease 1 (APE1), a critical enzyme involved in DNA repair and cellular response to oxidative stress. APE1 plays a vital role in base excision repair, maintaining genomic stability and contributing to cancer cell survival, particularly in tumors with high oxidative damage. By inhibiting APE1, APE1-IN-1 disrupts DNA repair mechanisms, sensitizing cancer cells to chemotherapy and radiation therapy. This compound is under investigation for its potential use in cancer treatment, particularly in overcoming resistance to DNA-damaging agents and enhancing the efficacy of existing therapies.
| CAS Number | 524708-03-0 |
| Synonyms | N-[3-(1,3-benzothiazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide |
| Molecular Formula | C19H21N3OS2 |
| Purity | ≥95% |
| IUPAC Name | N-[3-(1,3-benzothiazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamide |
| InChI | InChI=1S/C19H21N3OS2/c1-11(2)22-9-8-13-16(10-22)25-18(20-12(3)23)17(13)19-21-14-6-4-5-7-15(14)24-19/h4-7,11H,8-10H2,1-3H3,(H,20,23) |
| InChIKey | JMSPCTGDYFVMJZ-UHFFFAOYSA-N |
| SMILES | CC(C)N1CCC2=C(C1)SC(=C2C3=NC4=CC=CC=C4S3)NC(=O)C |
