Apholate

• CAT Number: I022315
• CAS Number: 52-46-0
• Molecular Formula: C12H24N9P3
• Molecular Weight: 387.31
• Purity: 98%
• Synonyms: Pholate; Apholate; AI3-26316; AI326316; AI3 26316
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 1,3,5,2,4,6-Triazatriphosphorine, 2,2,4,4,6,6-hexakis(1-aziridiny l)-2,2,4,4,6,6-hexahydro-
• InChI: InChI=1S/C12H24N9P3/c1-2-16(1)22(17-3-4-17)13-23(18-5-6-18,19-7-8-19)15-24(14-22,20-9-10-20)21-11-12-21/h1-12H2
• InChIKey: PXZAWHSJYIECNQ-UHFFFAOYSA-N
• SMILES: N1(P2(N3CC3)=NP(N4CC4)(N5CC5)=NP(N6CC6)(N7CC7)=N2)CC1

Apholate is a chemical used in pesticides that inhibits the organism's reproduction.

Reference

1: Haqqi TM. Sister-chromatid exchanges and chromosomal aberrations in lymphocytes of male albino rats treated with an alkylating agent, apholate (NSC 26, 812; ENT 26, 316). Mutat Res. 1984 Nov-Dec;141(3-4):175-81. PubMed PMID: 6239979.
2: Haqqi TM, Adhami UM. Testicular damage and change in serum LDH isozyme pattern induced by multiple sub-lethal doses of apholate in albino rats. Toxicol Lett. 1982 Jul;12(2-3):199-205. PubMed PMID: 6214049.
3: Mittal PK, Sheikher C, Nath V. Cytochemical changes induced by apholate, tepa and hempa during vitellogenesis in Locusta migratoria. Cytobios. 1980;28(111-112):161-4. PubMed PMID: 6163593.
4: Haqqi TM, Adhami UM. Effect of apholate (ENT 26316; NSC 26812) on nucleic acids, total protein content & activity levels of aminotransferases (GOT, GPT), alkaline phosphatase & 5′-nucleotidase in liver of male albino rats. Indian J Exp Biol. 1979 May;17(5):488-92. PubMed PMID: 230151.
5: Taneja SK, Sood V, Taneja S, Nath A. Effect of apholate on neurosecretion of pars intercerebralis, fat bodies & ovarian development of the red cotton bug Dysdercus koenigii (F). Indian J Exp Biol. 1979 Feb;17(2):133-8. PubMed PMID: 157974.
6: Haqqi TM, Adhami UM. Effect of apholate (NSC 26812; ENT 26316) on the nucleic acids & protein content in the spleen of male albino rats. Indian J Exp Biol. 1978 Jun;16(6):720-2. PubMed PMID: 151666.
7: Labrecque GC, Fye RL. Cytogenetic and other effects of the chemosterilants tepa, metepa, apholate an hempa in insects (a review). Mutat Res. 1978;47(2):99-113. Review. PubMed PMID: 75501.
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9: Saxena SC, Aditya V. Histopathology and histochemistry of insects treated with chemosterilants: IX. Tumor like growth in the ovary of Periplaneta americana (L) treated with apholate. Bull Environ Contam Toxicol. 1976 Apr;15(4):485-7. PubMed PMID: 130950.
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14: Saxena SC, Vikramaditya. Histopathology and histochemistry of the insects treated with chemosterilants. IV-on the seminal vesicles and accessory glands of Poicelocerus pictus treated with apholate and tepa. Bull Environ Contam Toxicol. 1973 Apr;9(4):218-21. PubMed PMID: 4131087.
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16: Painter RR, Kilgore WW, Gadallah AI. Influence of apholate on the haemolymph proteins of adult house flies. J Econ Entomol. 1972 Feb;65(1):23-7. PubMed PMID: 4257784.
17: Hafez M, Aboul-Nasr AE, Salama HS. Studies on the control of mosquitoes in Egypt by means of chemosterilants. IV. Sterilization of Anopheles pharoensis and Culex pipiens by apholate and thiotepa. J Econ Entomol. 1971 Jun;64(3):675-8. PubMed PMID: 5004301.
18: Grover KK, Pillai MK, Dass CM. Cytogenetic basis of chemically induced sterility in Culex pipiens fatigans Wiedemann. 3. Effect of apholate & hempa on DNA synthesis in the gonads. Indian J Exp Biol. 1971 Apr;9(2):150-2. PubMed PMID: 5092724.
19: Bransby-Williams WR. A field release of male Culex pipiens fatigans sterilised by apholate. East Afr Med J. 1971 Feb;48(2):68-75. PubMed PMID: 5088514.
20: Hafez M, Osman MF, Erakey MA. Studies on control of house flies in Egypt by chemosterilants. 3. Sterilization of Musca sorbens by apholate, tepa, and hempa. J Econ Entomol. 1970 Aug;63(4):1167-9. PubMed PMID: 5475198.