Api137 TFA

• CAT Number: I040033
• Molecular Formula: C104H171N37O22.xC2HF3O2
• Molecular Weight: 2291.71 (free acid)
• Purity: ≥95%

Api137 TFA (Cat No.: I040033) is a peptidomimetic inhibitor targeting the ribosome to block bacterial protein synthesis, making it a valuable tool in antibiotic and antimicrobial resistance research. It is derived from apidaecin, a proline-rich antimicrobial peptide (PrAMP) that disrupts translation elongation. The trifluoroacetate (TFA) salt enhances its solubility and stability for in vitro and in vivo applications. Api137 TFA is widely studied for its potential in developing novel antibiotics, particularly against drug-resistant bacterial strains, contributing to infectious disease research.

Reference

[1]. Florin T, et, al. An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome. Nat Struct Mol Biol. 2017 Sep;24(9):752-757.
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[2]. Graf M, et, al. Intracellular Antimicrobial Peptides Targeting the Protein Synthesis Machinery. Adv Exp Med Biol. 2019:1117:73-89.
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