Apigenin

• CAT Number: I003889
• CAS Number: 520-36-5
• Molecular Formula: C₁₅H₁₀O₅
• Molecular Weight: 270.2
• Purity: ≥95%
• Synonyms: Chamomile;Flavone;NSC 83244;Versulin
• Solubility: Soluble to 50 mM in DMSO
• Storage: Desiccate at +4°C
• InChI: InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
• InChIKey: KZNIFHPLKGYRTM-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O

Apigenin (CAT: I003889) is a naturally occurring flavonoid found in various plants, including parsley, chamomile, and celery. It has been studied for its potential pharmacological properties, including antioxidant, anti-inflammatory, and anticancer activities. Apigenin has been shown to possess antioxidant properties by scavenging free radicals and reducing oxidative stress in cells. It also exhibits anti-inflammatory effects by inhibiting inflammatory mediators and pathways. Moreover, apigenin has demonstrated anticancer properties by inhibiting the proliferation of cancer cells, inducing cell cycle arrest, and promoting apoptosis. Due to its diverse biological activities, apigenin is being investigated for its potential therapeutic applications in various diseases, including cancer, cardiovascular disorders, and neurodegenerative diseases.

Reference

1:Quantification of apigenin trimethyl ether in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pre-clinical pharmacokinetic study. Elhennawy MG, Lin HS.J Pharm Biomed Anal. 2017 Apr 22;142:35-41. doi: 10.1016/j.jpba.2017.03.070. [Epub ahead of print] PMID: 28494337
2:The Functional Characterization of a Site-Specific Apigenin 4/'-O-methyltransferase Synthesized by the Liverwort Species Plagiochasma appendiculatum. Liu H, Xu RX, Gao S, Cheng AX.Molecules. 2017 May 7;22(5). pii: E759. doi: 10.3390/molecules22050759. PMID: 28481281 Free Article
3:Development and evaluation of injectable nanosized drug delivery systems for apigenin. Karim R, Palazzo C, Laloy J, Delvigne AS, Vanslambrouck S, Jerome C, Lepeltier E, Orange F, Dogne JM, Evrard B, Passirani C, Piel G.Int J Pharm. 2017 Apr 27. pii: S0378-5173(17)30374-5. doi: 10.1016/j.ijpharm.2017.04.064. [Epub ahead of print] PMID: 28456651
4:Effects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary. Soyman Z, Kelekçi S, Sal V, Şevket O, Bayındır N, Uzun H.Balkan Med J. 2017 Apr 13. doi: 10.4274/balkanmedj.2016.1386. [Epub ahead of print] PMID: 28443590 Free Article
5:Synergistic effect of graphene oxide coated nanotised apigenin with paclitaxel (GO-NA/PTX): A ROS dependent mitochondrial mediated apoptosis in ovarian cancer. Pal MK, Jaiswar SP, Dwivedi A, Goyal S, Dwivedi VN, Pathak AK, Kumar V, Sankhwar PL, Ray RS.Anticancer Agents Med Chem. 2017 Apr 24. doi: 10.2174/1871520617666170425094549. [Epub ahead of print] PMID: 28443516
6:Apigenin inhibits TNFα/IL-1α-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells. Bauer D, Redmon N, Mazzio E, Soliman KF.PLoS One. 2017 Apr 25;12(4):e0175558. doi: 10.1371/journal.pone.0175558. eCollection 2017. PMID: 28441391 Free PMC Article
7:Apigenin inhibits renal cell carcinoma cell proliferation. Meng S, Zhu Y, Li JF, Wang X, Liang Z, Li SQ, Xu X, Chen H, Liu B, Zheng XY, Xie LP.Oncotarget. 2017 Mar 21;8(12):19834-19842. doi: 10.18632/oncotarget.15771. PMID: 28423637 Free PMC Article
8:Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. Feng X, Yu W, Li X, Zhou F, Zhang W, Shen Q, Li J, Zhang C, Shen P.Biochem Pharmacol. 2017 Apr 13. pii: S0006-2952(17)30231-9. doi: 10.1016/j.bcp.2017.04.014. [Epub ahead of print] PMID: 28414138
9:Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma. Li G, Chi CW, Shao XF, Fang CH.Biochem Biophys Res Commun. 2017 May 20;487(1):122-127. doi: 10.1016/j.bbrc.2017.04.029. Epub 2017 Apr 11. PMID: 28408212
10:Solubility and dissolution rate improvement of the inclusion complex of apigenin with 2-hydroxypropyl-β-cyclodextrin prepared using the liquid antisolvent precipitation and solvent removal combination methods. Wu W, Zu Y, Zhao X, Zhang X, Wang L, Li Y, Wang L, Zhang Y, Lian B.Drug Dev Ind Pharm. 2017 Apr 24:1-12. doi: 10.1080/03639045.2017.1318900. [Epub ahead of print] PMID: 28402147