Apilimod mesylate

• CAT Number: I011643
• CAS Number: 870087-36-8
• Molecular Formula: C₂₅H₃₄N₆O₈S₂
• Molecular Weight: 610.7
• Purity: ≥95%
• Synonyms: (E)-4-(6-(2-(3-methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dimethanesulfonate
• Target: PI3K/Akt/mTOR
• Solubility: Soluble in DMSO
• Storage: Store at -20C
• InChI: InChI=1S/C23H26N6O2.2CH4O3S/c1-18-5-4-6-19(15-18)17-25-28-21-16-22(29-10-13-30-14-11-29)27-23(26-21)31-12-8-20-7-2-3-9-24-20;2*1-5(2,3)4/h2-7,9,15-17H,8,10-14H2,1H3,(H,26,27,28);2*1H3,(H,2,3,4)/b25-17+
• InChIKey: GAJWNIKZLYZYSY-OKUPSQOASA-N
• SMILES: CC1=CC=CC(=C1)C=NNC2=NC(=NC(=C2)N3CCOCC3)OCCC4=CC=CC=N4.CS(=O)(=O)O.CS(=O)(=O)O

Apilimod mesylate(CAT: I011643) is a small molecule inhibitor of the PIKfyve kinase, which plays a key role in modulating intracellular trafficking pathways. By inhibiting PIKfyve, apilimod mesylate alters the endolysosomal pathway in immune cells, leading to a reduction in cytokine production and inflammatory responses. Apilimod mesylate has demonstrated potential as a therapeutic agent for the treatment of a variety of inflammatory diseases, including rheumatoid arthritis, Crohn’s disease, and COVID-19.