APIO-EE-07

• CAT Number: I047666
• CAS Number: 1606160-46-6
• Molecular Formula: C18H11FN2O4
• Molecular Weight: 338.29
• Purity: ≥95%
• IUPAC Name: (3E)-5-fluoro-3-[(E)-4-(4-nitrophenyl)-2-oxobut-3-enylidene]-1H-indol-2-one
• InChI: InChI=1S/C18H11FN2O4/c19-12-4-8-17-15(9-12)16(18(23)20-17)10-14(22)7-3-11-1-5-13(6-2-11)21(24)25/h1-10H,(H,20,23)/b7-3+,16-10+
• SMILES: C1=CC(=CC=C1/C=C/C(=O)/C=C/2\C3=C(C=CC(=C3)F)NC2=O)[N+](=O)[O-]

APIO-EE-07 is a dual-target inhibitor of RSK1 and MSK2. APIO-EE-07 inhibited cell growth and induced apoptosis and also increased expression of Bax as well as cleaved caspase-3 and -PARP in colon cancer cells by downregulating RSK1 and MSK2 downstream targets, including CREB and ATF1.
KEYWORDS: APIO-EE-07 | supplier | RSK1/MSK2 inhibitor | CAS [1606160-46-6] | Non Selective (Ribosomal proteins) | p90-RSK | MSK | Inhibitor | Enzymes | Colon cancer

Reference

G Jin et al. Discovery of a novel dual-target inhibitor against RSK1 and MSK2 to suppress growth of human colon cancer. Oncogene. 2020 Oct;39(43):6733-6746.