Apoptosis Activator 2

• CAT Number: I004894
• CAS Number: 79183-19-0
• Molecular Formula: C15H9Cl2NO2
• Molecular Weight: 306.1
• Purity: ≥95%
• Synonyms: 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione
• Target: Apoptosis
• Solubility: DMSO: ≥ 46 mg/mL
• Storage: 3 years -20C powder
• IC50: 4-9 uM(Leukemia origin cells)[1]
• InChI: InChI=1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H,8H2
• InChIKey: KGRJPLRFGLMQMV-UHFFFAOYSA-N
• SMILES: O=C1C(C2=CC=CC=C2N1CC3=CC=C(Cl)C(Cl)=C3)=O

Apoptosis Activator 2 (CAT: I004894) is a small molecule compound that has been reported to induce apoptosis, or programmed cell death, in various cancer cell lines. It functions by activating the intrinsic apoptotic pathway, leading to the activation of caspases and subsequent cell death. Apoptosis Activator 2 has been investigated for its potential therapeutic applications in cancer treatment, particularly as a sensitizer to enhance the efficacy of chemotherapy or radiation therapy. Further research is needed to fully understand its mechanism of action and evaluate its potential in clinical settings.

Reference

1:N Am J Med Sci. 2012 Nov;4(11):582-5. doi: 10.4103/1947-2714.103319. Nano – drug Delivery of Apoptosis Activator 2 to AGS Cells by Liposomes Conjugated with Anti-TROP2 Antibody.Farivar TN,Najafipour R,Johari P, PMID: 23181231 PMCID: PMC3503378 DOI: 10.4103/1947-2714.103319 Abstract: BACKGROUND: Gastric cancer is the second most common causes of cancer related death in the world and is responsible for two third of cancer related death in the developing countries. survival rate surgery is low and radiation therapy and chemotherapy as alternatives ways for treatment of gastric cancer are not very promising. Thus there is an urgent need for introducing novel treatment procedures and promising new anti-canceric drugs.AIM: In this study we used pre-prepared liposomes and after necessary manipulations ,these modified liposomes were used for delivery of apoptosis activator 2 to gastric adenocarcinoma cell line (AGS).MATERIALS AND METHODS: we used pre-prepared liposomes and after necessary manipulations, these modified liposomes were used for delivery of apoptosis activator 2 to AGS cells and induced apoptosis was evaluated by related apoptotic DNA ladder, TUNNEL and Cell Death experiments.RESULTS: Evaluation of apoptosis by Apoptotic DNA Ladder in liposome treated and untreated AGS cells by DNA laddering and fragmentation, TUNEL and Cell Death Detection confirmed that treatment of AGS cell lines with apoptosis activator 2 loaded liposomes which targeted cell surface TROP2 antigen in cancer cells significantly increased apoptosis in these cells.CONCLUSION: Nano drug delivery of apoptosis activator 2 to human gastric adenocarcinoma cell line with liposomes targeted TROP2 antigen is a possible way for smart killing of human gastric adenocarcinoma cells.