Apremilast-d5

• CAT Number: R022294
• CAS Number: 1258597-47-5
• Molecular Formula: C22H24N2O7S
• Molecular Weight: 465.53
• Purity: ≥95%
• Synonyms: (S)-2-[1-(3-Ethoxy-d5-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione; (S)-N-(2-(1-(3-Ethoxy-d5-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide; Apremilast-d5; CC 10004-d5
• Storage: 2°C to 8°C
• IUPAC Name: N-[2-[(1S)-1-[4-methoxy-3-(1,1,2,2,2-pentadeuterioethoxy)phenyl]-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide
• InChI: InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1/i1D3,5D2
• InChIKey: IMOZEMNVLZVGJZ-JVFKXMKASA-N
• SMILES: [2H]C([2H])([2H])C([2H])([2H])OC1=C(C=CC(=C1)[C@@H](CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC

Apremilast-d5（Cat No.:R022294） is a deuterated version of apremilast, containing five deuterium atoms, which enhances its analytical detection and stability in pharmacokinetic studies. This modification is vital for investigating apremilast’s therapeutic mechanisms in treating inflammatory conditions such as psoriasis and psoriatic arthritis. By providing clearer insights into the drug’s metabolism and distribution within the body, Apremilast-d5 facilitates the development of more effective dosing regimens and formulations. It is an indispensable tool for researchers to optimize and evaluate treatments for chronic inflammatory disorders.