Aprindine

• CAT Number: I002605
• CAS Number: 37640-71-4
• Molecular Formula: C22H30N2
• Molecular Weight: 322.49
• Purity: ≥95%
• Synonyms: Amidonal; Fiboran; Aprindin; Aprinidine; Fibocil; Aprindina; Aprindinum.;N/’-(2,3-dihydro-1H-inden-2-yl)-N,N-diethyl-N/’-phenylpropane-1,3-diamine
• Solubility: Soluble in DMSO, not in water
• Storage: Store at -20°C
• IUPAC Name: N'-(2,3-dihydro-1H-inden-2-yl)-N,N-diethyl-N'-phenylpropane-1,3-diamine
• InChI: InChI=1S/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3
• InChIKey: NZLBHDRPUJLHCE-UHFFFAOYSA-N
• SMILES: CCN(CC)CCCN(C1CC2=CC=CC=C2C1)C3=CC=CC=C3

Aprindine (Cat.No:I002605) is a Class 1b antiarrhythmic agent used to manage ventricular and supraventricular arrhythmias. In one study, it delayed atrial fibrillation more than digoxin did. It has shown effectiveness when given orally.

Reference

1:Comparison of the effects of bepridil and aprindine for the prevention of atrial fibrillation after cardiac and aortic surgery: A prospective randomized study. Ozawa M, Komatsu T, Sato Y, Kunugita F, Tachibana H, Tashiro A, Okabayashi H, Nakamura M.J Arrhythm. 2015 Oct;31(5):302-6. doi: 10.1016/j.joa.2015.04.003. Epub 2015 May 16. PMID: 26550087 Free PMC Article2:Bepridil enhances aprindine-induced prolongation of atrial effective refractory period in a canine atrial rapid pacing model. Nakatani Y, Sakamoto T, Nishida K, Kataoka N, Yamaguchi Y, Sakabe M, Fujiki A, Mizumaki K, Inoue H.J Cardiol. 2015 Nov;66(5):445-50. doi: 10.1016/j.jjcc.2015.06.001. Epub 2015 Jul 7. PMID: 26162947 Free Article3:Relationship between serum aprindine concentration and neurologic side effects in Japanese. Tsuchishita Y, Fukumoto K, Kusumoto M, Ueno K.Biol Pharm Bull. 2009 Apr;32(4):637-9. PMID: 19336897 Free Article4:Effect of antiarrhythmic agents on heart rate variability indices after myocardial infarction: comparative experimental study of aprindine and procainamide. Nogami Y, Takase B, Matsui T, Hattori H, Hamabe A, Fujita M, Ohsuzu F, Ishihara M, Maekara T.Biomed Pharmacother. 2005 Oct;59 Suppl 1:S169-73. PMID: 16275488 5:Proteasomal degradation of Kir6.2 channel protein and its inhibition by a Na+ channel blocker aprindine. Tanaka H, Miake J, Notsu T, Sonyama K, Sasaki N, Iitsuka K, Kato M, Taniguchi S, Igawa O, Yoshida A, Shigemasa C, Hoshikawa Y, Kurata Y, Kuniyasu A, Nakayama H, Inagaki N, Nanba E, Shiota G, Morisaki T, Ninomiya H, Kitakaze M, Hisatome I.Biochem Biophys Res Commun. 2005 Jun 17;331(4):1001-6. PMID: 15882977 6:Nonlinear pharmacokinetics of aprindine in guinea pigs. Shimizu M, Ohota T, Kishida M, Ogata H.Drug Metab Pharmacokinet. 2002;17(4):292-9. PMID: 15618680 Free Article7:Drug-induced changes in fibrillation cycle length and organization index can predict chemical cardioversion of long-lasting atrial fibrillation with bepridil alone or in combination with aprindine. Fujiki A, Sakabe M, Nishida K, Sugao M, Tsuneda T, Iwamoto J, Mizumaki K, Inoue H.Circ J. 2004 Dec;68(12):1139-45. PMID: 15564697 Free Article8:Maintenance of sinus rhythm and recovery of atrial mechanical function after cardioversion with bepridil or in combination with aprindine in long-lasting persistent atrial fibrillation. Fujiki A, Tsuneda T, Sakabe M, Nakagawa K, Mizumaki K, Hirai T, Inoue H.Circ J. 2004 Sep;68(9):834-9. PMID: 15329504 Free Article9:[Comparison of the efficacies of disopyramide, cibenzoline and aprindine for the termination of paroxysmal and persistent atrial fibrillation in elderly and non-elderly patients]. Komatsu T, Nakamura S, Suzuki O, Yomogida K, Horiuchi D, Abe N, Kameda K, Owada S, Tomita H, Oikawa K, Okumura K.J Cardiol. 2003 Apr;41(4):191-8. Japanese. PMID: 12728540 10:Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation. Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H; Sinus Rhythm Maintenance in Atrial Fibrillation Randomized Trial (SMART) Investigators..Circ J. 2002 Jun;66(6):553-6. PMID: 12074271 Free Article