AR 231453

• CAT Number: I004729
• CAS Number: 733750-99-7
• Molecular Formula: C21H24FN7O5S
• Molecular Weight: 505.52
• Purity: ≥95%
• Target: Neuronal Signaling
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• IUPAC Name: N-(2-fluoro-4-methylsulfonylphenyl)-5-nitro-6-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]pyrimidin-4-amine
• InChI: InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25)
• InChIKey: DGBKNTVAKIFYNU-UHFFFAOYSA-N
• SMILES: CC(C)C1=NOC(=N1)C2CCN(CC2)C3=NC=NC(=C3[N+](=O)[O-])NC4=C(C=C(C=C4)S(=O)(=O)C)F

AR 231453（Cat No.:I004729）is a selective and potent antagonist of the metabotropic glutamate receptor 5 (mGluR5), a G-protein-coupled receptor involved in neurotransmission and various neurophysiological processes. By blocking mGluR5, AR 231453 is studied for its potential therapeutic effects in neurological and psychiatric disorders, including anxiety, depression, and fragile X syndrome. The compound has been shown to modulate glutamate signaling, which is implicated in several brain functions such as learning, memory, and mood regulation. Preclinical studies suggest AR 231453 may offer a novel approach to treating disorders linked to glutamatergic dysfunction, though more research is needed.

Reference

[1]. Chu ZL, et al. A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology. 2007 Jun;148(6):2601-9.
[2]. Chu ZL, et al. A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release. Endocrinology. 2008 May;149(5):2038-47.
[3]. Semple G, et al. Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119. J Med Chem. 2008 Sep 11;51(17):5172-5.