AR antagonist 1

• CAT Number: I016344
• CAS Number: 1818885-54-9
• Molecular Formula: C₁₅H₁₉ClN₂O
• Molecular Weight: 278.78
• Purity: ≥95%
• Target: Ligands for E3 Ligase
• IUPAC Name: 4-(3-amino-2,2,4,4-tetramethylcyclobutyl)oxy-2-chlorobenzonitrile
• InChI: InChI=1S/C15H19ClN2O/c1-14(2)12(18)15(3,4)13(14)19-10-6-5-9(8-17)11(16)7-10/h5-7,12-13H,18H2,1-4H3
• InChIKey: ZMQAQKRIAFCCDB-UHFFFAOYSA-N
• SMILES: CC1(C(C(C1OC2=CC(=C(C=C2)C#N)Cl)(C)C)N)C

AR Antagonist 1(CAT: I016344) is a selective androgen receptor (AR) antagonist with pivotal applications in oncology and endocrinology research. It inhibits AR signaling by competitively binding to the receptor, blocking androgen-mediated transcriptional activity. This mechanism is critical for studying hormone-dependent cancers, such as prostate cancer, and conditions like androgen insensitivity syndrome. AR Antagonist 1 supports investigations into AR-related signaling pathways, drug resistance, and the development of novel therapeutic strategies targeting AR dysregulation. Its specificity makes it an essential tool for advancing research in AR-driven pathologies and endocrine disorders.