For research use only. Not for therapeutic Use.
Selective galanin GAL<sub>2</sub> receptor agonist (IC<sub>50</sub> values are 1.76 and 879 nM for GAL<sub>2</sub> and GAL<sub>1</sub> respectively). Also shows moderate affinity for GAL<sub>3</sub> receptors (K<sub>i</sub> values are 88 and 271 nM for GAL<sub>2</sub> and GAL<sub>3</sub> respectively). Antiepileptogenic agent; prevents full seizures and postkindling increases in hippocampal excitability.
| Catalog Number | P000185 |
| CAS Number | 367518-31-8 |
| Synonyms | Alternative Name: Gal(2-11)amide |
| Molecular Formula | C54H81N13O14 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble to 1 mg/ml in 20% formic acid |
| Storage | Desiccate at -20C |
| IUPAC Name | (2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]butanediamide |
| InChI | InChI=1S/C54H81N13O14/c1-26(2)17-37(46(57)73)62-49(76)38(18-27(3)4)63-51(78)40(20-31-13-15-33(70)16-14-31)61-44(72)24-59-47(74)29(7)60-53(80)42(25-68)66-52(79)41(22-43(56)71)64-50(77)39(19-28(5)6)65-54(81)45(30(8)69)67-48(75)35(55)21-32-23-58-36-12-10-9-11-34(32)36/h9-16,23,26-30,35,37-42,45,58,68-70H,17-22,24-25,55H2,1-8H3,(H2,56,71)(H2,57,73)(H,59,74)(H,60,80)(H,61,72)(H,62,76)(H,63,78)(H,64,77)(H,65,81)(H,66,79)(H,67,75)/t29-,30+,35-,37-,38-,39-,40-,41-,42-,45-/m0/s1 |
| InChIKey | SUJPPMXJCZETOA-ZKEPBWIVSA-N |
| SMILES | CC(C)CC(C(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)CNC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(C(C)O)NC(=O)C(CC2=CNC3=CC=CC=C32)N |
