For research use only. Not for therapeutic Use.
Anandamide (AEA) was the first endogenous cannabinoid to be isolated and characterized as an agonist acting on the same receptors (CB<sub>1</sub> and CB<sub>2</sub>) as tetrahydrocannabinol (THC). Arachidonoyl 2-<wbr></wbr>chloroethylamide (ACEA) is a potent, stable, and selective agonist analog of AEA. ACEA has a K<sub>i</sub> value of 1.4 nM at the isolated rat CB<sub>1</sub> receptor, and is 1,400 times more potent at the CB<sub>1</sub> compared with the CB<sub>2</sub> receptor. In whole animal experiments, ACEA induces hypothermia in mice with the same efficacy as AEA, in spite of its much higher affinity for the CB<sub>1</sub> receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.
| Catalog Number | R052776 |
| CAS Number | 220556-69-4 |
| Synonyms | (5Z,8Z,11Z,14Z)-N-(2-Chloroethyl)-5,8,11,14-eicosatetraenamide; ACEA; |
| Molecular Formula | C22H36ClNO |
| Purity | ≥95% |
| Storage | -80°C |
| InChIKey | vQNMGLLFMPXVFN-GOSISDBHSA-N |
