For research use only. Not for therapeutic Use.
ARB-272572 is a potent small-molecule PD-L1 inhibitor with an IC50 value of 400 pM.
| Catalog Number | I045213 |
| CAS Number | 2368182-63-0 |
| Synonyms | 5-[(2-hydroxyethylamino)methyl]-N-[3-[3-[[5-[(2-hydroxyethylamino)methyl]pyridine-2-carbonyl]amino]-2-methylphenyl]-2-methylphenyl]pyridine-2-carboxamide |
| Molecular Formula | C32H36N6O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C32H36N6O4/c1-21-25(5-3-7-27(21)37-31(41)29-11-9-23(19-35-29)17-33-13-15-39)26-6-4-8-28(22(26)2)38-32(42)30-12-10-24(20-36-30)18-34-14-16-40/h3-12,19-20,33-34,39-40H,13-18H2,1-2H3,(H,37,41)(H,38,42) |
| InChIKey | FZEPAZRIEAMJFE-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC=C1NC(=O)C2=NC=C(C=C2)CNCCO)C3=C(C(=CC=C3)NC(=O)C4=NC=C(C=C4)CNCCO)C |
| Reference | [1]. Park JJ, et al. Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1. Nat Commun. 2021 Feb 22;12(1):1222. |
