For research use only. Not for therapeutic Use.
Arctigenin（Cat No.:I004863）is a lignan compound derived from the seeds of Arctium lappa (burdock), recognized for its potent biological activities. Known for its anti-inflammatory, antioxidant, and anticancer properties, Arctigenin has attracted attention in pharmaceutical research. It exhibits selective cytotoxicity against cancer cells and has shown promise in modulating immune responses and inhibiting viral replication. Additionally, Arctigenin is studied for its neuroprotective effects, with potential benefits for conditions like Alzheimer’s disease. This natural compound continues to be a focus in the development of therapeutic agents for diverse medical applications.
| Catalog Number | I004863 |
| CAS Number | 7770-78-7 |
| Synonyms | (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one |
| Molecular Formula | C21H24O6 |
| Purity | ≥95% |
| Target | MEK1/2 |
| Solubility | DMSO：34 mg/ml; 25 mM in ethanol； |
| Storage | Desiccate at -20°C |
| IUPAC Name | (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one |
| InChI | InChI=1S/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3/t15-,16+/m0/s1 |
| InChIKey | NQWVSMVXKMHKTF-JKSUJKDBSA-N |
| SMILES | COC1=C(C=C(C=C1)C[C@H]2COC(=O)[C@@H]2CC3=CC(=C(C=C3)O)OC)OC |
| Reference | </br>1:Arctigenin induced gallbladder cancer senescence through modulating epidermal growth factor receptor pathway. Zhang M, Cai S, Zuo B, Gong W, Tang Z, Zhou D, Weng M, Qin Y, Wang S, Liu J, Ma F, Quan Z.Tumour Biol. 2017 May;39(5):1010428317698359. doi: 10.1177/1010428317698359. PMID: 28459363 </br>2:Synthesis and antitumour activity of arctigenin amino acid ester derivatives against H22 hepatocellular carcinoma. Cai E, Guo S, Yang L, Han M, Xia J, Zhao Y, Gao X, Wang Y.Nat Prod Res. 2017 Apr 18:0-6. doi: 10.1080/14786419.2017.1314279. [Epub ahead of print] PMID: 28415847 </br>3:Biodistribution of arctigenin-loaded nanoparticles designed for multimodal imaging. Cui Q, Hou Y, Wang Y, Li X, Liu Y, Ma X, Wang Z, Wang W, Tao J, Wang Q, Jiang M, Chen D, Feng X, Bai G.J Nanobiotechnology. 2017 Apr 7;15(1):27. doi: 10.1186/s12951-017-0263-8. PMID: 28388905 Free PMC Article</br>4:Arctigenin, a natural lignan compound, induces G<sub>0</sub>/G<sub>1</sub> cell cycle arrest and apoptosis in human glioma cells. Maimaitili A, Shu Z, Cheng X, Kaheerman K, Sikandeer A, Li W.Oncol Lett. 2017 Feb;13(2):1007-1013. doi: 10.3892/ol.2016.5474. Epub 2016 Dec 8. PMID: 28356992 Free PMC Article</br>5:β-Catenin Mediates Anti-adipogenic and Anticancer Effects of Arctigenin in Preadipocytes and Breast Cancer Cells. Lee J, Imm JY, Lee SH.J Agric Food Chem. 2017 Mar 29;65(12):2513-2520. doi: 10.1021/acs.jafc.7b00112. Epub 2017 Mar 15. PMID: 28279068 </br>6:Protective effect of arctigenin on ethanol-induced neurotoxicity in PC12 cells. Huang J, Xiao L, Wei JX, Shu YH, Fang SQ, Wang YT, Lu XM.Mol Med Rep. 2017 Apr;15(4):2235-2240. doi: 10.3892/mmr.2017.6222. Epub 2017 Feb 21. PMID: 28260103 </br>7:The anti-metastatic effects of the phytoestrogen arctigenin on human breast cancer cell lines regardless of the status of ER expression. Maxwell T, Chun SY, Lee KS, Kim S, Nam KS.Int J Oncol. 2017 Feb;50(2):727-735. doi: 10.3892/ijo.2016.3825. Epub 2016 Dec 29. PMID: 28035371 </br>8:Arctigenin protects against neuronal hearing loss by promoting neural stem cell survival and differentiation. Huang X, Chen M, Ding Y, Wang Q.Genesis. 2017 Mar;55(3). doi: 10.1002/dvg.23016. Epub 2017 Feb 13. PMID: 28026149 </br>9:Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin. Brecht K, Riebel V, Couttet P, Paech F, Wolf A, Chibout SD, Pognan F, Krähenbühl S, Uteng M.Toxicol In Vitro. 2017 Apr;40:55-65. doi: 10.1016/j.tiv.2016.12.001. Epub 2016 Dec 5. PMID: 27923774 </br>10:Gastroprotective effects of arctigenin of <i>Arctium lappa</i> L. on a rat model of gastric ulcers. Li XM, Miao Y, Su QY, Yao JC, Li HH, Zhang GM.Biomed Rep. 2016 Nov;5(5):589-594. Epub 2016 Oct 4. PMID: 27882222 Free PMC Article |
