For research use only. Not for therapeutic Use.
ARD-1676(CAT: I040684) is a potent small-molecule androgen receptor degrader (ARD) designed to target and eliminate androgen receptor (AR) proteins through the ubiquitin-proteasome system, rather than merely blocking receptor activity. This approach is particularly effective in treating castration-resistant prostate cancer (CRPC), where AR signaling remains active despite hormone suppression. By degrading both wild-type and mutant AR, ARD-1676 helps overcome resistance to conventional AR antagonists. It is widely studied in oncology and targeted protein degradation (TPD) research as a promising therapeutic strategy for AR-driven cancers. ARD-1676 offers a novel mechanism with strong potential for next-generation prostate cancer treatments.
| CAS Number | 2632305-36-1 |
| Synonyms | 2-chloro-4-[(3S)-8-[4-[4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-5,7-dihydropyrrolo[3,4-f]isoindol-6-yl]methyl]piperidine-1-carbonyl]phenyl]-3-methyl-2,8-diazaspiro[4.5]decan-2-yl]benzonitrile |
| Molecular Formula | C44H46ClN7O5 |
| Purity | ≥95% |
| IUPAC Name | 2-chloro-4-[(3S)-8-[4-[4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-5,7-dihydropyrrolo[3,4-f]isoindol-6-yl]methyl]piperidine-1-carbonyl]phenyl]-3-methyl-2,8-diazaspiro[4.5]decan-2-yl]benzonitrile |
| InChI | InChI=1S/C44H46ClN7O5/c1-27-21-44(26-51(27)34-7-4-30(22-46)37(45)20-34)12-16-49(17-13-44)33-5-2-29(3-6-33)41(55)50-14-10-28(11-15-50)23-48-24-31-18-35-36(19-32(31)25-48)43(57)52(42(35)56)38-8-9-39(53)47-40(38)54/h2-7,18-20,27-28,38H,8-17,21,23-26H2,1H3,(H,47,53,54)/t27-,38?/m0/s1 |
| InChIKey | GAXWAKXJBZHVQF-ZVENJKCTSA-N |
| SMILES | CC1CC2(CCN(CC2)C3=CC=C(C=C3)C(=O)N4CCC(CC4)CN5CC6=CC7=C(C=C6C5)C(=O)N(C7=O)C8CCC(=O)NC8=O)CN1C9=CC(=C(C=C9)C#N)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
