Aristolactam I

• CAT Number: R058062
• CAS Number: 13395-02-3
• Molecular Formula: C17H11NO4
• Molecular Weight: 293.28
• Purity: ≥95%
• Synonyms: 8-Methoxybenzo[f]-1,3-benzodioxolo[6,5,4-cd]indol-5(6H)-one; ?Aristolactam; Aristolactam I; Aristololactam; Aristololactam I; NSC 87406;
• Target: Caspase
• Storage: -20°C
• IUPAC Name: 14-methoxy-3,5-dioxa-10-azapentacyclo[9.7.1.02,6.08,19.013,18]nonadeca-1(18),2(6),7,11(19),12,14,16-heptaen-9-one
• InChI: InChI=1S/C17H11NO4/c1-20-12-4-2-3-8-9(12)5-11-14-10(17(19)18-11)6-13-16(15(8)14)22-7-21-13/h2-6H,7H2,1H3,(H,18,19)
• InChIKey: MXOKGWUJNGEKBH-UHFFFAOYSA-N
• SMILES: COC1=CC=CC2=C3C4=C(C=C21)NC(=O)C4=CC5=C3OCO5

Aristolactam I（Cat No.:R058062）is a toxic compound derived from the plant genus Aristolochia, known for its alkaloid constituents, particularly aristolactams. It is formed as a result of the metabolic conversion of aristolochic acids, which are found in certain Aristolochia species. Aristolactam I is implicated in nephrotoxicity and carcinogenicity, as it can bind to DNA and cause mutations, leading to kidney damage and an increased risk of cancer. Its toxicity has been associated with the use of Aristolochia in traditional medicine, and its presence has raised concerns regarding the safety of these plant species in herbal remedies.