For research use only. Not for therapeutic Use.
Aristolochic acid is a carcinogen found in Aristolochia and Radix. It inhibits PLA2 and decreases GABA-induced release of arachidonic acid and phosphatidylcholine.
| Catalog Number | R006705 |
| CAS Number | 313-67-7 |
| Synonyms | 8-Methoxy-6-nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic Acid; Aristolochine; Aristolochia A; Aristolochic Acid; Aristolochic Acid 1; Aristolochic Acid I; NSC 11926; NSC 50413; TR 1736; Tardolyt; |
| Molecular Formula | C17H11NO7 |
| Purity | ≥95% |
| Target | NF-κB |
| Storage | -20°C |
| InChI | InChI=1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20) |
| InChIKey | BBFQZRXNYIEMAW-UHFFFAOYSA-N |
| SMILES | COC1=CC=CC2=C3C(=C(C=C21)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O |
| Reference | </br>1:Aristolochic acid, a plant extract used in the treatment of pain and linked to Balkan endemic nephropathy, is a regulator of K2P channels. Veale EL, Mathie A.Br J Pharmacol. 2016 May;173(10):1639-52. doi: 10.1111/bph.13465. Epub 2016 Apr 5. PMID: 26914156 Free PMC Article</br>2:Prediction and Characterisation of the System Effects of Aristolochic Acid: A Novel Joint Network Analysis towards Therapeutic and Toxicological Mechanisms. Nie W, Lv Y, Yan L, Chen X, Lv H.Sci Rep. 2015 Dec 1;5:17646. doi: 10.1038/srep17646. PMID: 26620132 Free PMC Article</br>3:[Research on biological detoxification of Chinese medicine containing aristolochic acid A by ten microorganisms]. Cao Y, Tan ZJ, Xia BH, Xie JC, Lin LM, Liao DF.Zhongguo Zhong Yao Za Zhi. 2015 May;40(10):1939-44. Chinese. PMID: 26390652 </br>4:[Trace analysis of aristolochic acid A]. Liu Y, Gao H, Wang Z, Zhang Q.Zhongguo Zhong Yao Za Zhi. 2010 Dec;35(24):3314-7. Chinese. PMID: 21438398 </br>5:[The determination of aristolochic acid A in different processed Aristolochia manshuriensis and the test of influence about renal function in rats]. Pan JH, Yan GJ, Song J.Zhong Yao Cai. 2010 Aug;33(8):1228-33. Chinese. PMID: 21213532 </br>6:[Analysis of aristolochic acid A from the aerial and underground parts of Asarum by UPLC-UV]. Xue Y, Tong XH, Wang F, Zhao WG.Yao Xue Xue Bao. 2008 Feb;43(2):221-3. Chinese. PMID: 18507353 </br>7:Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy. Stiborová M, Frei E, Arlt VM, Schmeiser HH.Mutat Res. 2008 Jan-Feb;658(1-2):55-67. Epub 2007 Aug 6. Review. PMID: 17851120 </br>8:[Determination of aristolochic acid A in Guanxinsuhe preparations by RP-HPLC]. Li L, Gao HM, Wang ZM, Wang WH.Zhongguo Zhong Yao Za Zhi. 2006 Jan;31(2):122-4. Chinese. PMID: 16570797 </br>9:[Determination of aristolochic acid A in Radix Aristolociae and Herba Asari by RP-HPLC]. Jiang X, Wang ZM, You LS, Dai LP, Ding GZ.Zhongguo Zhong Yao Za Zhi. 2004 May;29(5):408-10. Chinese. PMID: 15706888 </br>10:Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer? Arlt VM, Ferluga D, Stiborova M, Pfohl-Leszkowicz A, Vukelic M, Ceovic S, Schmeiser HH, Cosyns JP.Int J Cancer. 2002 Oct 10;101(5):500-2. No abstract available. PMID: 12216081 Free Article |
