For research use only. Not for therapeutic Use.
ARL-17477 is a dual inhibitor of NOS1and the autophagy-lysosomal system with anticancer activity and can inhibit tumor growth in KRAS-mutated cancers[1].
| Catalog Number | I010740 |
| CAS Number | 866914-87-6 |
| Synonyms | N’-[4-[2-[(3-chlorophenyl)methylamino]ethyl]phenyl]thiophene-2-carboximidamide;dihydrochloride |
| Molecular Formula | C20H22Cl3N3S |
| Purity | ≥95% |
| InChI | InChI=1S/C20H20ClN3S.2ClH/c21-17-4-1-3-16(13-17)14-23-11-10-15-6-8-18(9-7-15)24-20(22)19-5-2-12-25-19;;/h1-9,12-13,23H,10-11,14H2,(H2,22,24);2*1H |
| InChIKey | SOXBYIKSUDXMIE-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)Cl)CNCCC2=CC=C(C=C2)N=C(C3=CC=CS3)N.Cl.Cl |
| Reference | [1]. Teiko Komori Nomura, et al. ARL-17477 is a dual inhibitor of NOS1 and the autophagic-lysosomal system that prevents tumor growth in vitro and in vivo. Sci Rep. 2023 Jul 4;13(1):10757. |
