ARN23746

• CAT Number: I022448
• CAS Number: 2497525-96-7
• Molecular Formula: C17H25F3N2O4S
• Molecular Weight: 410.45
• Purity: 98%
• Synonyms: ARN23746; ARN 23746; ARN-23746
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 3-(N,N-dimethylsulfamoyl)-4-((8,8,8-trifluorooctyl)amino)benzoic acid
• InChI: InChI=1S/C17H25F3N2O4S/c1-22(2)27(25,26)15-12-13(16(23)24)8-9-14(15)21-11-7-5-3-4-6-10-17(18,19)20/h8-9,12,21H,3-7,10-11H2,1-2H3,(H,23,24)
• InChIKey: ZAJDYPRGNPKHEI-UHFFFAOYSA-N
• SMILES: O=C(O)C1=CC(S(=O)(N(C)C)=O)=C(NCCCCCCCC(F)(F)F)C=C1

ARN23746(CAT: I022448) is a selective inhibitor of the Na-K-2Cl cotransporter 1 (NKCC1), under investigation for its potential to treat core symptoms associated with Down syndrome. By inhibiting NKCC1 activity, ARN23746 reduces intracellular chloride levels, restoring the balance of inhibitory and excitatory neurotransmission. This mechanism is crucial for improving cognitive function and neural plasticity in Down syndrome. With its high specificity and favorable pharmacological profile, ARN23746 is a valuable tool for studying NKCC1-mediated pathways and developing targeted therapies for neurodevelopmental disorders. It is suitable for in vitro and in vivo research aimed at advancing treatment options for Down syndrome.