For research use only. Not for therapeutic Use.
ARN24139 is an orally active topoisomerase II poison with an IC50 value of 7.3 μM against human topoIIα. ARN24139 showed antiproliferative activity against DU145, HeLa and A549 cell lines with IC50 values of 4.7 μM, 3.8 μM and 3.1 μM, respectively.
KEYWORDS: ARN24139 | Supplier | TOPO II poison | ARN 24139 | ARN-24139 | CAS [2699768-78-8] | DNA-RNA | TOPO | Poison | Enzymes
| Catalog Number | I047655 |
| CAS Number | 2699768-78-8 |
| Molecular Formula | C24H16F3N3O4S |
| Purity | ≥95% |
| IUPAC Name | 4,6-dioxo-1,3-diphenyl-2-sulfanylidene-N-[3-(trifluoromethoxy)phenyl]-1,3-diazinane-5-carboxamide |
| InChI | InChI=1S/C24H16F3N3O4S/c25-24(26,27)34-18-13-7-8-15(14-18)28-20(31)19-21(32)29(16-9-3-1-4-10-16)23(35)30(22(19)33)17-11-5-2-6-12-17/h1-14,19H,(H,28,31) |
| SMILES | C1=CC=C(C=C1)N2C(=O)C(C(=O)N(C2=S)C3=CC=CC=C3)C(=O)NC4=CC(=CC=C4)OC(F)(F)F |
| Reference | JM Arencibia et al. Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons With Promising Antiproliferative Activity. J Med Chem. 2020 Apr 9;63(7):3508-3521. |
