For research use only. Not for therapeutic Use.
ARN726 is a potent NAAA (N-acylethanolamine acid amidase) inhibitor with an IC50 of 0.073 µM. ARN726 decreases alcohol self-administration in a dose-dependent manner[1][2].
| Catalog Number | I022452 |
| CAS Number | 1628343-77-0 |
| Synonyms | 4-cyclohexylbutyl N-[(3S)-2-oxoazetidin-3-yl]carbamate |
| Molecular Formula | C14H24N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H24N2O3/c17-13-12(10-15-13)16-14(18)19-9-5-4-8-11-6-2-1-3-7-11/h11-12H,1-10H2,(H,15,17)(H,16,18)/t12-/m0/s1 |
| InChIKey | FNLUJRBWJBUJTC-LBPRGKRZSA-N |
| SMILES | C1CCC(CC1)CCCCOC(=O)NC2CNC2=O |
| Reference | [1]. Fotio Y, et al. N-acylethanolamine acid amidase (NAAA) inhibition decreases the motivation for alcohol in Marchigian Sardinian alcohol-preferring rats. Psychopharmacology (Berl). 2021 Jan;238(1):249-258. [2]. Petracca R, et al. Novel activity-based probes for N-acylethanolamine acid amidase. Chem Commun (Camb). 2017 Aug 22;53(86):11810-11813. |
