Arnicolide D

• CAT Number: I018389
• CAS Number: 34532-68-8
• Molecular Formula: C₁₉H₂₄O₅
• Molecular Weight: 332.39
• Purity: ≥95%
• Target: PI3K/Akt/mTOR
• IUPAC Name: [(1S,3aR,5R,5aR,8aR,9S,9aR)-1,5,8a-trimethyl-2,8-dioxo-3a,4,5,5a,9,9a-hexahydro-1H-azuleno[6,5-b]furan-9-yl] 2-methylprop-2-enoate
• InChI: InChI=1S/C19H24O5/c1-9(2)17(21)24-16-15-11(4)18(22)23-13(15)8-10(3)12-6-7-14(20)19(12,16)5/h6-7,10-13,15-16H,1,8H2,2-5H3/t10-,11+,12+,13-,15-,16+,19+/m1/s1
• InChIKey: NZESEVTYUVXOTC-APDQSUQKSA-N
• SMILES: C[C@@H]1C[C@@H]2[C@@H]([C@@H](C(=O)O2)C)[C@@H]([C@]3([C@H]1C=CC3=O)C)OC(=O)C(=C)C

Arnicolide D(Cat No.:I018389) is a natural compound derived from Centipede minima. It exhibits various pharmacological activities and has shown potential as an anticancer agent. Arnicolide D modulates the cell cycle, induces apoptosis through the activation of the caspase signaling pathway, and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. It has been found to inhibit the viability of Nasopharyngeal carcinoma (NPC) cells in a concentration- and time-dependent manner. The multifaceted effects of Arnicolide D make it a promising candidate for further research and development in the field of cancer therapeutics.

Reference

[1]. Liu R, et al. Arnicolide D, from the herb Centipeda minima, Is a Therapeutic Candidate against Nasopharyngeal Carcinoma. Molecules. 2019 May 17;24(10).