For research use only. Not for therapeutic Use.
ARRY-380 analog, an inhibitor of EGFR (ErbB1), is extracted from patent WO2015153959A2, compound 249[1]. ARRY-380 is a potent, selective, ATP-competitive, orally active inhibitor of HER2[2].
| Catalog Number | I005571 |
| CAS Number | 937265-83-3 |
| Synonyms | 6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]quinazolin-4-amine |
| Molecular Formula | C29H27N7O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C29H27N7O4S/c1-19-13-21(4-7-26(19)39-22-9-11-36-28(15-22)32-18-34-36)35-29-24-14-20(3-6-25(24)31-17-33-29)27-8-5-23(40-27)16-30-10-12-41(2,37)38/h3-9,11,13-15,17-18,30H,10,12,16H2,1-2H3,(H,31,33,35) |
| InChIKey | QVMNYGOVNWWFKF-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC(=C1)NC2=NC=NC3=C2C=C(C=C3)C4=CC=C(O4)CNCCS(=O)(=O)C)OC5=CC6=NC=NN6C=C5 |
| Reference | [1]. Zaneta Nikolovska-Coleska, et al. Small molecule inhibitors of mcl-1 and uses thereof. WO2015153959A2. |
