For research use only. Not for therapeutic Use.
ARS-1323-alkyne(CAT: I019005) is a chemical compound known as a switch-II pocket (S-IIP) inhibitor. It functions as a conformation-specific chemical reporter, specifically targeting the nucleotide state of KRASG12C in living cells. By interacting with the switch-II pocket of KRASG12C, ARS-1323-alkyne can selectively probe and modulate the activity of this mutant form of KRAS. This compound enables researchers to study and manipulate the nucleotide state of KRASG12C, providing insights into its signaling pathways and potentially aiding in the development of therapeutic strategies for KRAS-driven cancers.
| Catalog Number | I019005 |
| CAS Number | 2436544-27-1 |
| Molecular Formula | C₂₈H₂₇ClF₂N₆O₃ |
| Purity | ≥95% |
| Target | MAPK/ERK Pathway |
| Reference | [1]. Lou K,et al. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 May 28;12(583). pii: eaaw9450. |
