ART-IN-1

• CAT Number: I043717
• CAS Number: 2418014-98-7
• Molecular Formula: C14H13NO2S
• Molecular Weight: 259.32
• Purity: ≥95%
• Synonyms: 8-propan-2-yloxy-4H-thieno[2,3-c]isoquinolin-5-one
• InChI: InChI=1S/C14H13NO2S/c1-8(2)17-9-3-4-10-12(7-9)11-5-6-18-14(11)15-13(10)16/h3-8H,1-2H3,(H,15,16)
• InChIKey: RRNITWOICYYQGQ-UHFFFAOYSA-N
• SMILES: CC(C)OC1=CC2=C(C=C1)C(=O)NC3=C2C=CS3

ART-IN-1 (compound 7) is a selective PARP inhibitor with IC50s of 19, 22, 2.4, >100, 1.1 µM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively[1].
ART-IN-1 (compound 7) (0-100 µM) shows inhibition of PARP2, TNKS2, PARP10, PARP14, PARP15 with IC50s of 19, 22, 2.4, >100, 1.1 µM, respectively[1].

Reference

[1]. Maksimainen MM, et al. Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs. Bioorg Med Chem. 2021;52:116511.
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