ARTD3/PARP3-IN-1

• CAT Number: I041147
• CAS Number: 730949-09-4
• Molecular Formula: C17H16N4O2
• Molecular Weight: 308.33
• Purity: ≥95%
• Synonyms: 3-(4-oxo-3H-quinazolin-2-yl)-N-(pyridin-2-ylmethyl)propanamide
• InChI: InChI=1S/C17H16N4O2/c22-16(19-11-12-5-3-4-10-18-12)9-8-15-20-14-7-2-1-6-13(14)17(23)21-15/h1-7,10H,8-9,11H2,(H,19,22)(H,20,21,23)
• InChIKey: LHJLGHGHHDKLMY-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=O)NC(=N2)CCC(=O)NCC3=CC=CC=N3

ARTD3/PARP3-IN-1 (Cat No.: I041147) is a selective inhibitor of PARP3 (also known as ARTD3), a member of the poly(ADP-ribose) polymerase family involved in DNA repair and chromatin remodeling. By specifically targeting PARP3, this compound allows researchers to study its unique role in double-strand break repair and cell cycle regulation without affecting other PARP isoforms. ARTD3/PARP3-IN-1 is valuable for exploring the therapeutic potential of PARP3 inhibition in cancer and genomic stability research. For research use only in laboratory and preclinical settings.

Reference

[1]. Lindgren AE, et al. Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3. J Med Chem. 2013 Dec 12;56(23):9556-68.
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