Artemether

• CAT Number: A000567
• CAS Number: 71963-77-4
• Molecular Formula: C16H26O5
• Molecular Weight: 298.40
• Purity: ≥95%
• Synonyms: Beta-Artemether; Dihydroartemisinin methyl ether; Artenam; 71963-77-4; Artemetherum
• Target: Antimalaria
• Solubility: >15.3mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: (1R,4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane
• InChI: InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
• InChIKey: SXYIRMFQILZOAM-HVNFFKDJSA-N
• SMILES: C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC)C

Artemether（Cat No.:A000567）is a fast-acting antimalarial drug derived from artemisinin, a natural compound from the Artemisia annua plant. It is primarily used to treat severe Plasmodium falciparum malaria, often in combination therapies to prevent resistance. Artemether works by generating reactive oxygen species (ROS) that damage the parasite’s proteins and membranes, leading to its death. Its rapid action reduces parasite load and alleviates symptoms effectively. With a well-tolerated safety profile, Artemether is a cornerstone in modern malaria treatment and a vital component in global efforts to combat the disease.

Reference

1: Hasegawa C, Kudo M, Maruyama H, Kimura M. Severe delayed haemolytic anaemia
associated with artemether-lumefantrine treatment of malaria in a Japanese
traveller. J Infect Chemother. 2017 Nov 7. pii: S1341-321X(17)30241-6. doi:
10.1016/j.jiac.2017.10.008. [Epub ahead of print] PubMed PMID: 29127021.

2: Challenger JD, Bruxvoort K, Ghani AC, Okell LC. Assessing the impact of
imperfect adherence to artemether-lumefantrine on malaria treatment outcomes
using within-host modelling. Nat Commun. 2017 Nov 9;8(1):1373. doi:
10.1038/s41467-017-01352-3. PubMed PMID: 29123086.

3: Zhao X, Guo X, Yue W, Wang J, Yang J, Chen J. Artemether suppresses cell
proliferation and induces apoptosis in diffuse large B cell lymphoma cells. Exp
Ther Med. 2017 Nov;14(5):4083-4090. doi: 10.3892/etm.2017.5063. Epub 2017 Aug 29.
PubMed PMID: 29104626; PubMed Central PMCID: PMC5658687.

4: van der Meulen T, Lee S, Noordeloos E, Donaldson CJ, Adams MW, Noguchi GM,
Mawla AM, Huising MO. Artemether Does Not Turn α Cells into β Cells. Cell Metab.
2017 Nov 1. pii: S1550-4131(17)30614-9. doi: 10.1016/j.cmet.2017.10.002. [Epub
ahead of print] PubMed PMID: 29103923.

5: Mangrio FA, Dwivedi P, Han S, Zhao G, Gao D, Si T, Xu RX. Characteristics of
Artemether-Loaded Poly(lactic-co-glycolic) Acid Microparticles Fabricated by
Coaxial Electrospray: Validation of Enhanced Encapsulation Efficiency and
Bioavailability. Mol Pharm. 2017 Nov 14. doi: 10.1021/acs.molpharmaceut.7b00862.
[Epub ahead of print] PubMed PMID: 29096443.

6: Moore BR, Davis WA, Clarke PM, Robinson LJ, Laman M, Davis TME.
Cost-effectiveness of artemisinin-naphthoquine versus artemether-lumefantrine for
the treatment of uncomplicated malaria in Papua New Guinean children. Malar J.
2017 Oct 30;16(1):438. doi: 10.1186/s12936-017-2081-8. PubMed PMID: 29084540;
PubMed Central PMCID: PMC5663042.

7: Huang L, Carey V, Lindsey JC, Marzan F, Gingrich D, Graham B, Barlow-Mosha L,
Ssemambo PK, Kamthunzi P, Nachman S, Parikh S, Aweeka FT; IMPAACT P1079 protocol
team. Concomitant nevirapine impacts pharmacokinetic exposure to the antimalarial
artemether-lumefantrine in African children. PLoS One. 2017 Oct
24;12(10):e0186589. doi: 10.1371/journal.pone.0186589. eCollection 2017. PubMed
PMID: 29065172; PubMed Central PMCID: PMC5655345.

8: Ali S, Jafery N, Farhat K, Waheed A. Mini Review – Analysis of Artemether and
Dihydroartemisinin by high performance high liquid chromatography in biological
fluids-issues and solutions. Pak J Pharm Sci. 2017 Jul;30(4):1395-1401. PubMed
PMID: 29039344.

9: Tian L, Liu J, Jia Q, Ying Y, Yang Z, Huang G. Preparation and Evaluation of
Artemether Liposomes for Enhanced Anti-Tumor Therapy. AAPS PharmSciTech. 2017 Oct
16. doi: 10.1208/s12249-017-0896-9. [Epub ahead of print] PubMed PMID: 29038986.

10: Abd El-Aal NF, Hamza RS, Magdy M. Anti-angiogenic and anti-lymphangiogenic
role of praziquantel and artemether in experimental mansoniasis. Acta Parasitol.
2017 Dec 20;62(4):708-716. doi: 10.1515/ap-2017-0085. PubMed PMID: 29035850.