Artemotil

• CAT Number: I004811
• CAS Number: 75887-54-6
• Molecular Formula: C17H28O5
• Molecular Weight: 312.40
• Purity: ≥95%
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: Store at -20°C
• IUPAC Name: (1R,4S,5R,8S,9R,10S,12R,13R)-10-ethoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane
• InChI: InChI=1S/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17-/m1/s1
• InChIKey: NLYNIRQVMRLPIQ-XQLAAWPRSA-N
• SMILES: CCO[C@@H]1[C@@H]([C@@H]2CC[C@H]([C@H]3[C@]24[C@H](O1)O[C@@](CC3)(OO4)C)C)C

Artemotil (Cat No.:I004811), also known as β-arteether, is an antimalarial agent derived from artemisinin. It belongs to the artemisinin class of drugs, which are highly effective against Plasmodium falciparum, the parasite responsible for the most severe form of malaria. Artemotil exhibits potent antimalarial activity by inhibiting the growth and replication of the malaria parasite within red blood cells. It is particularly effective against multidrug-resistant strains of malaria. Artemotil is commonly used in combination therapies for the treatment of uncomplicated malaria, providing rapid parasite clearance and reducing the risk of treatment failure. Its unique mode of action and efficacy make it an important component in the fight against malaria, a significant global health burden.

Reference

[1]. Looareesuwan S, et al. Dose-finding and efficacy study for i.m. artemotil (beta-arteether) and comparison with i.m. artemether in acute uncomplicated P. falciparum malaria. Br J Clin Pharmacol. 2002 May;53(5):492-500.