ARUK2001607

• CAT Number: I042358
• CAS Number: 2924824-56-4
• Molecular Formula: C14H13N3O2S2
• Molecular Weight: 319.40
• Purity: ≥95%
• Synonyms: 6-methyl-N-(4-methylsulfonylphenyl)thieno[2,3-d]pyrimidin-4-amine
• InChI: InChI=1S/C14H13N3O2S2/c1-9-7-12-13(15-8-16-14(12)20-9)17-10-3-5-11(6-4-10)21(2,18)19/h3-8H,1-2H3,(H,15,16,17)
• InChIKey: QVQHWPLHUNEREE-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(N=CN=C2S1)NC3=CC=C(C=C3)S(=O)(=O)C

ARUK2001607 is a selective phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with a Kd of 7.1 nM. ARUK2001607 shows high selectivity over other >150 kinases[1].
In Vivo Mouse Pharmacokinetics Parameters for Selected ARUK2001607 (15) (5 mg/kg; ip Administration)[1]

T1/2 (h)
AUC (hr·ng/mL)
[plasma] at 0.5h (ng/mL)
[brain] at 0.5h (ng/g)
Kp

ARUK2001607 (15)
0.74
4520
2773
1590
0.58

Reference

[1]. Timothy P C Rooney, et al. The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. J Med Chem. 2022 Dec 14.
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