ARUK3001185

• CAT Number: I043662
• CAS Number: 2411969-39-4
• Molecular Formula: C9H4Cl2F3N3
• Molecular Weight: 282.05
• Purity: ≥95%
• Synonyms: 1-[2,4-dichloro-3-(trifluoromethyl)phenyl]triazole
• InChI: InChI=1S/C9H4Cl2F3N3/c10-5-1-2-6(17-4-3-15-16-17)8(11)7(5)9(12,13)14/h1-4H
• InChIKey: XVFXHCLMGYJAQI-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C(=C1N2C=CN=N2)Cl)C(F)(F)F)Cl

ARUK3001185 (Compound 8l) is a potent, selective, orally active and brain-penetrant inhibitor of Notum activity with an IC50 of 6.7 nM[1].

Reference

[1]. Willis NJ, et al. Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. J Med Chem. 2022 May 26;65(10):7212-7230.
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