ARV-825

• CAT Number: I002360
• CAS Number: 1818885-28-7
• Molecular Formula: C46H47ClN8O9S
• Molecular Weight: 923.43
• Purity: 98%
• Target: BRD4
• Solubility: 10 mM in DMSO
• Appearance: Solid powder
• Storage: Store at -20°C
• IC50: ＜1nM (DC50)
• IUPAC Name: 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]acetamide
• InChI: InChI=1S/C46H47ClN8O9S/c1-26-27(2)65-46-39(26)41(29-7-9-30(47)10-8-29)50-35(42-53-52-28(3)54(42)46)25-38(57)49-31-11-13-32(14-12-31)64-24-23-63-22-21-62-20-19-61-18-17-48-34-6-4-5-33-40(34)45(60)55(44(33)59)36-15-16-37(56)51-43(36)58/h4-14,35-36,48H,15-25H2,1-3H3,(H,49,57)(H,51,56,58)/t35-,36?/m0/s1
• InChIKey: RWLOGRLTDKDANT-TYIYNAFKSA-N
• SMILES: CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NC4=CC=C(C=C4)OCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C8=CC=C(C=C8)Cl)C

ARV-825（Cat No.:I002360）is a novel proteolysis-targeting chimera (PROTAC) that targets and degrades the BET (bromodomain and extra-terminal) family of proteins. By recruiting the E3 ubiquitin ligase to BET proteins, ARV-825 facilitates their ubiquitination and subsequent degradation by the proteasome. This mechanism disrupts the transcription of genes critical for cancer cell growth and survival. ARV-825 shows potential in treating hematologic malignancies and solid tumors, offering a unique therapeutic approach by degrading rather than inhibiting oncogenic proteins. Its efficacy and specificity make ARV-825 a promising candidate in cancer therapy research.