For research use only. Not for therapeutic Use.
AS1134900 is a highly selective, allosteric and uncompetitive NADP+-dependent malic enzyme 1 (ME1) inhibitor[1].
| Catalog Number | I043329 |
| CAS Number | 149760-98-5 |
| Synonyms | 6-[(7-methyl-2-propylimidazo[4,5-b]pyridin-4-yl)methyl]-2-[2-(2H-tetrazol-5-yl)phenyl]-1,3-benzothiazole |
| Molecular Formula | C25H22N8S |
| Purity | ≥95% |
| InChI | InChI=1S/C25H22N8S/c1-3-6-21-27-22-15(2)11-12-33(24(22)28-21)14-16-9-10-19-20(13-16)34-25(26-19)18-8-5-4-7-17(18)23-29-31-32-30-23/h4-5,7-13H,3,6,14H2,1-2H3,(H,29,30,31,32) |
| InChIKey | LGDMZWWVVLGYPR-UHFFFAOYSA-N |
| SMILES | CCCC1=NC2=C(C=CN(C2=N1)CC3=CC4=C(C=C3)N=C(S4)C5=CC=CC=C5C6=NNN=N6)C |
| Reference | [1]. Yoshida T, et al. Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP+-Dependent Malic Enzyme 1. Biochemistry. 2022 Jul 12. |
