For research use only. Not for therapeutic Use.
AS1708727（Cat No.:I015349） is a potent orally active inhibitor of Foxo1 with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively. It inhibits the expression of gluconeogenic genes and suppresses increases in blood glucose levels. The compound shows promising potential as a therapeutic agent for the treatment of type 2 diabetes and related metabolic disorders.
| Catalog Number | I015349 |
| CAS Number | 1253226-93-5 |
| Molecular Formula | C₂₄H₂₄Cl₂N₂O₂ |
| Purity | ≥95% |
| Target | Autophagy |
| Storage | Store at -20°C |
| IUPAC Name | 2-cyclopentyl-N-[2,4-dichloro-3-(isoquinolin-5-yloxymethyl)phenyl]-N-methylacetamide |
| InChI | InChI=1S/C24H24Cl2N2O2/c1-28(23(29)13-16-5-2-3-6-16)21-10-9-20(25)19(24(21)26)15-30-22-8-4-7-17-14-27-12-11-18(17)22/h4,7-12,14,16H,2-3,5-6,13,15H2,1H3 |
| InChIKey | OZEZQEPCCWFFJQ-UHFFFAOYSA-N |
| SMILES | CN(C1=C(C(=C(C=C1)Cl)COC2=CC=CC3=C2C=CN=C3)Cl)C(=O)CC4CCCC4 |
