AS1842856

• CAT Number: I002883
• CAS Number: 836620-48-5
• Molecular Formula: C18H22FN3O3
• Molecular Weight: 347.38
• Purity: ≥95%
• Synonyms: AS1842856; AS-1842856; AS 1842856.;5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• Target: Autophagy
• Solubility: Soluble in DMSO
• Storage: -20°C
• IUPAC Name: 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxoquinoline-3-carboxylic acid
• InChI: InChI=1S/C18H22FN3O3/c1-2-22-9-11(18(24)25)17(23)14-13(22)8-12(15(19)16(14)20)21-10-6-4-3-5-7-10/h8-10,21H,2-7,20H2,1H3,(H,24,25)
• InChIKey: MOMCHYGXXYBDCD-UHFFFAOYSA-N
• SMILES: CCN1C=C(C(=O)C2=C1C=C(C(=C2N)F)NC3CCCCC3)C(=O)O

AS1842856（Cat No.:I002883） is a potent cell-permeable inhibitor that specifically targets the transcriptional activity of Foxo1, a key regulator of cellular processes. It exhibits an IC50 of 33nM and binds directly to activated Foxo1. Interestingly, it does not interact with phosphorylated Foxo1 at Ser256. In addition to inhibiting Foxo1, AS1842856 also demonstrates inhibitory effects on autophagy. This compound shows promise in the field of cellular regulation and may have potential applications in diseases where Foxo1 and autophagy play critical roles.