AS2863619 free base

• CAT Number: I017844
• CAS Number: 2241300-50-3
• Molecular Formula: C₁₆H₁₂N₈O
• Molecular Weight: 332.32
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 4-[1-(2-methyl-3H-benzimidazol-5-yl)imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine
• InChI: InChI=1S/C16H12N8O/c1-8-19-10-3-2-9(6-11(10)20-8)24-13-4-5-18-7-12(13)21-16(24)14-15(17)23-25-22-14/h2-7H,1H3,(H2,17,23)(H,19,20)
• InChIKey: OORKHRHPVSWORX-UHFFFAOYSA-N
• SMILES: CC1=NC2=C(N1)C=C(C=C2)N3C4=C(C=NC=C4)N=C3C5=NON=C5N

AS2863619 free base（Cat No.:I017844）is a potent and selective inhibitor of the enzyme diacylglycerol acyltransferase 2 (DGAT2), which plays a key role in triglyceride biosynthesis. By inhibiting DGAT2, AS2863619 reduces triglyceride production, offering potential therapeutic benefits for metabolic disorders such as non-alcoholic fatty liver disease (NAFLD), obesity, and dyslipidemia. Preclinical studies have demonstrated its efficacy in lowering lipid accumulation in the liver and improving insulin sensitivity. AS2863619 free base is a promising candidate for the development of treatments aimed at addressing lipid-related metabolic disorders and cardiovascular risk factors.

Reference

[1]. Akamatsu M, et al. Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19. Sci Immunol. 2019 Oct 25;4(40). pii: eaaw2707.