AS2863619

• CAT Number: I017843
• CAS Number: 2241300-51-4
• Molecular Formula: C₁₆H₁₄Cl₂N₈O
• Molecular Weight: 405.24
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 4-[1-(2-methyl-3H-benzimidazol-5-yl)imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine;dihydrochloride
• InChI: InChI=1S/C16H12N8O.2ClH/c1-8-19-10-3-2-9(6-11(10)20-8)24-13-4-5-18-7-12(13)21-16(24)14-15(17)23-25-22-14;;/h2-7H,1H3,(H2,17,23)(H,19,20);2*1H
• InChIKey: LHUAALWRORLTCJ-UHFFFAOYSA-N
• SMILES: CC1=NC2=C(N1)C=C(C=C2)N3C4=C(C=NC=C4)N=C3C5=NON=C5N.Cl.Cl

AS2863619（Cat No.:I017843）is a selective and potent inhibitor of the CXCR4 receptor, playing a crucial role in cancer metastasis and immune cell trafficking. By blocking CXCR4, AS2863619 disrupts the CXCL12/CXCR4 signaling axis, which is involved in tumor progression and metastasis, making it valuable for cancer research. Additionally, it holds potential for applications in stem cell mobilization and immune response modulation. AS2863619’s high affinity and selectivity make it a key tool for studying CXCR4-related pathways and their therapeutic implications in oncology and immunology.

Reference

[1]. Akamatsu M, et al. Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19. Sci Immunol. 2019 Oct 25;4(40). pii: eaaw2707.