For research use only. Not for therapeutic Use.
AS408 is a novel allosteric modulator of the β2-adrenergic receptor (β2AR), binding to the membrane-facing surface of transmembrane segments 3 and 5.
| Catalog Number | I022496 |
| Synonyms | AS408; AS 408; AS-408; |
| Molecular Formula | C14H11BrN4 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 6-bromo-N2-phenylquinazoline-2,4-diamine |
| InChI | InChI=1S/C14H11BrN4/c15-9-6-7-12-11(8-9)13(16)19-14(18-12)17-10-4-2-1-3-5-10/h1-8H,(H3,16,17,18,19) |
| InChIKey | MPGNABXYXOGUGH-UHFFFAOYSA-N |
| SMILES | NC1=C2C=C(Br)C=CC2=NC(NC3=CC=CC=C3)=N1 |
| Reference | 1: Liu X, Kaindl J, Korczynska M, Stößel A, Dengler D, Stanek M, Hübner H, Clark MJ, Mahoney J, Matt RA, Xu X, Hirata K, Shoichet BK, Sunahara RK, Kobilka BK, Gmeiner P. An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor. Nat Chem Biol. 2020 Jul;16(7):749-755. doi: 10.1038/s41589-020-0549-2. Epub 2020 Jun 1. PMID: 32483378. |
