For research use only. Not for therapeutic Use.
AS601245 (CAT: I003266) is a compound known for its inhibitory activity against the c-Jun NH2-terminal kinase (JNK). JNK is a protein kinase that plays a crucial role in various cellular processes, including stress response, apoptosis, and inflammation. By targeting and inhibiting JNK, AS601245 may have therapeutic implications in diseases where JNK signaling is dysregulated, such as inflammatory disorders, neurodegenerative diseases, and certain types of cancer. The inhibition of JNK by AS601245 could provide insights into the modulation of these pathways and contribute to the development of potential treatments for related conditions.
| Catalog Number | I003266 |
| CAS Number | 345987-15-7 |
| Synonyms | (Z)-2-(benzo[d]thiazol-2-yl)-2-(2-((2-(pyridin-3-yl)ethyl)imino)-1,2-dihydropyrimidin-4-yl)acetonitrile |
| Molecular Formula | C₂₀H₁₆N₆S |
| Purity | ≥95% |
| Target | JNK |
| Solubility | DMSO: ≥ 35 mg/mL |
| Storage | Store at -20°C |
| IC50 | 150nM (hJNK1), 220nM (hJNK2), 70 nM (hJNK3) |
| InChI | InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,25H,7,10H2,(H,23,24,26)/b19-15+ |
| InChIKey | AVLYNJZZQYEFEA-XDJHFCHBSA-N |
| SMILES | C1=CC=C2C(=C1)NC(=C(C#N)C3=NC(=NC=C3)NCCC4=CN=CC=C4)S2 |
| Reference | </br>1:Rosiglitazone and AS601245 decrease cell adhesion and migration through modulation of specific gene expression in human colon cancer cells. Cerbone A, Toaldo C, Minelli R, Ciamporcero E, Pizzimenti S, Pettazzoni P, Roma G, Dianzani MU, Ullio C, Ferretti C, Dianzani C, Barrera G.PLoS One. 2012;7(6):e40149. doi: 10.1371/journal.pone.0040149. Epub 2012 Jun 28. PMID: 22761953 Free PMC Article</br>2:AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells. Cerbone A, Toaldo C, Pizzimenti S, Pettazzoni P, Dianzani C, Minelli R, Ciamporcero E, Roma G, Dianzani MU, Canaparo R, Ferretti C, Barrera G.PPAR Res. 2012;2012:269751. doi: 10.1155/2012/269751. Epub 2012 Feb 29. PMID: 22619672 Free PMC Article</br>3:AS601245, a c-Jun NH2-terminal kinase (JNK) inhibitor, reduces axon/dendrite damage and cognitive deficits after global cerebral ischaemia in gerbils. Carboni S, Boschert U, Gaillard P, Gotteland JP, Gillon JY, Vitte PA.Br J Pharmacol. 2008 Jan;153(1):157-63. Epub 2007 Nov 19. PMID: 18026128 Free PMC Article</br>4:AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties. Carboni S, Hiver A, Szyndralewiez C, Gaillard P, Gotteland JP, Vitte PA.J Pharmacol Exp Ther. 2004 Jul;310(1):25-32. Epub 2004 Feb 26. PMID: 14988419 Free Article |
