Asarylaldehyde

• CAT Number: I003578
• CAS Number: 4460-86-0
• Molecular Formula: C10H12O4
• Molecular Weight: 196.2
• Purity: ≥95%
• Synonyms: 2,4,5-trimethoxybenzaldehyde
• Target: COX
• Solubility: 10 mM in DMSO
• Storage: Room Temperature
• InChI: InChI=1S/C10H12O4/c1-12-8-5-10(14-3)9(13-2)4-7(8)6-11/h4-6H,1-3H3
• InChIKey: IAJBQAYHSQIQRE-UHFFFAOYSA-N
• SMILES: COC1=CC(=C(C=C1C=O)OC)OC

Asaraldehyde（Cat No.: I003578）, is a natural compound known for its ability to inhibit cyclooxygenase-2 (COX-2), an enzyme involved in inflammation and pain. It exhibits notable selectivity, with a 17-fold preference for inhibiting COX-2 over COX-1, which helps minimize unwanted side effects associated with non-selective COX inhibitors. Additionally, 2,4,5-Trimethoxybenzaldehyde, a component of asaraldehyde, is utilized as a pharmaceutical intermediate. Its primary application lies in the synthesis of asarone, a compound with potential medicinal properties. Asaraldehyde’s anti-inflammatory properties make it valuable in research and potentially for the development of anti-inflammatory drugs.

Reference

[1]. Wu MR, et al. 2,4,5-TMBA, a natural inhibitor of cyclooxygenase-2, suppresses adipogenesis and promotes lipolysis in 3T3-L1 adipocytes. J Agric Food Chem. 2012 Jul 25;60(29):7262-9.
[2]. Chen CC, et al. Production of a COX-2 inhibitor, 2,4,5-trimethoxybenzaldehyde, with submerged cultured Antrodia camphorata. Lett Appl Microbiol. 2007 Apr;44(4):387-92.