Asiatic Acid

• CAT Number: R039716
• CAS Number: 464-92-6
• Molecular Formula: C30H48O5
• Molecular Weight: 488.70
• Purity: ≥95%
• Synonyms: 2a,3β,23-Trihydroxyurs-12-en-28-oic Acid; 2α,23-Dihydroxyursolic Acid; 2α,3β,19,23-Tetrahydroxy-urs-12-en-28-oic Acid; 2α,3β,23-Trihydroxyurs-12-en-28-oic Acid; Dammarolic Acid; NSC 166063
• Target: Anti-infection
• Storage: 3 years -20C powder
• IUPAC Name: (1S,2R,4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid Computed by Lexichem TK 2.7.0 (PubChem release 2021.10.14)
• InChI: InChI=1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1
• InChIKey: JXSVIVRDWWRQRT-UYDOISQJSA-N
• SMILES: C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(C[C@H]([C@@H]([C@@]5(C)CO)O)O)C)C)[C@@H]2[C@H]1C)C)C(=O)O

Asiatic acid（Cat No.:R039716）is a triterpenoid compound primarily derived from the Centella asiatica plant, commonly known as gotu kola. It has been extensively studied for its medicinal properties, including anti-inflammatory, antioxidant, and wound-healing effects. Asiatic acid promotes collagen synthesis, making it beneficial for skin health and regeneration. Research also suggests potential neuroprotective and cognitive enhancement properties, indicating its role in supporting brain health. Additionally, it may exhibit anticancer effects by inhibiting tumor growth. Overall, asiatic acid shows promise in various therapeutic applications and continues to be a subject of scientific investigation.

Reference

1:ASIATIC ACID INFLUENCES GLUCOSE HOMEOSTASIS IN P. BERGHEI MURINE MALARIA INFECTED SPRAGUE-DAWLEY RATS. Alfred MG, Nkazimulo MB, Vuyisile MM, Tagumirwa MC.Afr J Tradit Complement Altern Med. 2016 Aug 12;13(5):91-101. doi: 10.21010/ajtcam.v13i5.13. eCollection 2016. PMID: 28487899
2:Retraction of /Antioxidative and Antiinflammatory Activities of Asiatic Acid, Glycyrrhizic Acid, and Oleanolic Acid in Human Bronchial Epithelial Cells/. Tsao SM, Yin MC.J Agric Food Chem. 2017 Apr 19;65(15):3251. doi: 10.1021/acs.jafc.7b01473. Epub 2017 Apr 6. No abstract available. PMID: 28381084
3:Asiatic acid ameliorates pulmonary fibrosis induced by bleomycin (BLM) via suppressing pro-fibrotic and inflammatory signaling pathways. Dong SH, Liu YW, Wei F, Tan HZ, Han ZD.Biomed Pharmacother. 2017 May;89:1297-1309. doi: 10.1016/j.biopha.2017.03.005. Epub 2017 Mar 17. PMID: 28320097
4:The anti-inflammatory effects of asiatic acid in lipopolysaccharide-stimulated human corneal epithelial cells. Chen H, Hua XM, Ze BC, Wang B, Wei L.Int J Ophthalmol. 2017 Feb 18;10(2):179-185. doi: 10.18240/ijo.2017.02.01. eCollection 2017. PMID: 28251074 Free PMC Article
5:Pharmacological effects of asiatic acid in glioblastoma cells under hypoxia. Thakor FK, Wan KW, Welsby PJ, Welsby G.Mol Cell Biochem. 2017 Jun;430(1-2):179-190. doi: 10.1007/s11010-017-2965-5. Epub 2017 Feb 15. PMID: 28205096
6:Neurotrophic Effect of Asiatic acid, a Triterpene of Centella asiatica Against Chronic 1-Methyl 4-Phenyl 1, 2, 3, 6-Tetrahydropyridine Hydrochloride/Probenecid Mouse Model of Parkinson/'s disease: The Role of MAPK, PI3K-Akt-GSK3β and mTOR Signalling Pathways. Nataraj J, Manivasagam T, Justin Thenmozhi A, Essa MM.Neurochem Res. 2017 May;42(5):1354-1365. doi: 10.1007/s11064-017-2183-2. Epub 2017 Feb 8. PMID: 28181071
7:Asiatic acid inhibits lung cancer cell growth in vitro and in vivo by destroying mitochondria. Wu T, Geng J, Guo W, Gao J, Zhu X.Acta Pharm Sin B. 2017 Jan;7(1):65-72. doi: 10.1016/j.apsb.2016.04.003. Epub 2016 Jun 20. PMID: 28119810 Free PMC Article
8:Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation. Qi Z, Ci X, Huang J, Liu Q, Yu Q, Zhou J, Deng X.Biomed Pharmacother. 2017 Apr;88:252-259. doi: 10.1016/j.biopha.2017.01.067. Epub 2017 Jan 19. PMID: 28110191
9:A novel synthetic Asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing STAT3 signaling pathway. Wang G, Jing Y, Cao L, Gong C, Gong Z, Cao X.Onco Targets Ther. 2016 Dec 20;10:55-66. doi: 10.2147/OTT.S121619. eCollection 2017. PMID: 28053540 Free PMC Article
10:Asiatic acid attenuates pre-neoplastic lesions, oxidative stress, biotransforming enzymes and histopathological alterations in 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis. Siddique AI, Mani V, Arivalagan S, Thomas NS, Namasivayam N.Toxicol Mech Methods. 2017 Feb;27(2):136-150. doi: 10.1080/15376516.2016.1273422. Epub 2017 Jan 11. PMID: 28004603