ASK1-IN-1

• CAT Number: I001054
• CAS Number: 1262041-49-5
• Molecular Formula: C23H21N7O
• Molecular Weight: 411.46
• Purity: ≥95%
• Target: ASK1[1]
• Solubility: DMSO: ≤ 15.5 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 4-(4-cyclopropylimidazol-1-yl)-N-[3-(4-cyclopropyl-1,2,4-triazol-3-yl)phenyl]pyridine-2-carboxamide
• InChI: InChI=1S/C23H21N7O/c31-23(20-11-19(8-9-24-20)29-12-21(25-13-29)15-4-5-15)27-17-3-1-2-16(10-17)22-28-26-14-30(22)18-6-7-18/h1-3,8-15,18H,4-7H2,(H,27,31)
• InChIKey: ZGCMQKWOUIMBEP-UHFFFAOYSA-N
• SMILES: C1CC1C2=CN(C=N2)C3=CC(=NC=C3)C(=O)NC4=CC=CC(=C4)C5=NN=CN5C6CC6

ASK1-IN-1（Cat No.:I001054）is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), a key player in the MAPK signaling pathway involved in cellular responses to stress, oxidative stress, and apoptosis. By inhibiting ASK1, this compound prevents the activation of downstream kinases like JNK and p38 MAPK, which are associated with inflammation, cell death, and neurodegeneration. ASK1-IN-1 is widely used in research focused on diseases such as cardiovascular disorders, neurodegenerative diseases, and cancer, where abnormal ASK1 signaling contributes to disease progression, making it a valuable tool for therapeutic exploration.

Reference

[1].
Grant Raymond BUDAS, et al. Methods of treating pulmonary hypertension. WO2016025474A1.