Asp-AMS

• CAT Number: I019749
• CAS Number: 828288-98-8
• Molecular Formula: C₁₄H₁₉N₇O₉S
• Molecular Weight: 461.41
• Purity: ≥95%
• Target: Aminoacyl-tRNA Synthetase
• IUPAC Name: (3S)-3-amino-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxysulfonylamino]-4-oxobutanoic acid
• InChI: InChI=1S/C14H19N7O9S/c15-5(1-7(22)23)13(26)20-31(27,28)29-2-6-9(24)10(25)14(30-6)21-4-19-8-11(16)17-3-18-12(8)21/h3-6,9-10,14,24-25H,1-2,15H2,(H,20,26)(H,22,23)(H2,16,17,18)/t5-,6+,9+,10+,14+/m0/s1
• InChIKey: KMRBRMHHDAUXAY-UFIIOMENSA-N
• SMILES: C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COS(=O)(=O)NC(=O)[C@H](CC(=O)O)N)O)O)N

Asp-AMS (Cat No.:I019749) is a chemical compound used in scientific research, often in the context of proteomics and peptide synthesis. It typically refers to a modified form of aspartic acid, where AMS (4-acetamido-2-methylphenylsulfonyl) is a functional group attached to the amino acid. This modification can help in the identification, isolation, or study of specific proteins or peptides in complex biological mixtures. Asp-AMS may also be used in drug development or therapeutic applications, particularly in targeting protein interactions or enzymatic activity. However, its use is primarily academic, and further research is ongoing for potential clinical applications.

Reference

[1]. Messmer M, et al. Peculiar inhibition of human mitochondrial aspartyl-tRNA synthetase by adenylate analogs. Biochimie. 2009 May;91(5):596-603.