For research use only. Not for therapeutic Use.
Aspidin BB is a phloroglucinol derivative, which can be isolated from the aerial part of Dryopteris championii. Aspidin BB has anticancer activity. Aspidin BB induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells[1][2].
Aspidin BB (0-100 μM, 24-72 h) significantly inhibits HO-8910 cell proliferation in a dose- and time-dependent manner. The IC50 values are 15.02, 25.79 and 68.81 μM after 72, 48 and 24 h treatment, respectively[1].
Aspidin BB suppresses Bcl-2 expression and enhances Bax expression to desintegrate the outer mitochondrial membrane, then causes cytochrome c release which leads to the activation of effector caspase-3, and further cleaves the poly ADP-ribose polymerase (PARP) in the nucleus, finally induces cell apoptosis[1].
Aspidin BB provokes S phase arrest in HO-8910 cells with up-regulation of pRb, E2F1, CDK2, cyclin E and cyclin A proteins[1].
| Catalog Number | I022554 |
| CAS Number | 584-28-1 |
| Synonyms | 2-butanoyl-4-[(3-butanoyl-2,6-dihydroxy-4-methoxy-5-methylphenyl)methyl]-3,5-dihydroxy-6,6-dimethylcyclohexa-2,4-dien-1-one |
| Molecular Formula | C25H32O8 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H32O8/c1-7-9-15(26)17-20(29)13(19(28)12(3)22(17)33-6)11-14-21(30)18(16(27)10-8-2)24(32)25(4,5)23(14)31/h28-31H,7-11H2,1-6H3 |
| InChIKey | PLGZOIJJUOHZJA-UHFFFAOYSA-N |
| SMILES | CCCC(=O)C1=C(C(=C(C(C1=O)(C)C)O)CC2=C(C(=C(C(=C2O)C)OC)C(=O)CCC)O)O |
| Reference | [1]. Sun Y, et al. Aspidin BB, a phloroglucinol derivative, induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells. Chem Biol Interact. 2013 Jul 5;204(2):88-97. [2]. Chen NH, et al. Drychampones A-C: Three Meroterpenoids from Dryopteris championii. J Org Chem. 2016 Oct 7;81(19):9443-9448. |
