AST 487

• CAT Number: I004374
• CAS Number: 630124-46-8
• Molecular Formula: C26H30F3N7O2
• Molecular Weight: 529.61
• Purity: ≥95%
• Synonyms: 1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea
• Target: RET
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 0.88 uM
• InChI: InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37)
• InChIKey: ODPGGGTTYSGTGO-UHFFFAOYSA-N
• SMILES: CNC1=CC(OC2=CC=C(NC(NC3=CC=C(CN4CCN(CC)CC4)C(C(F)(F)F)=C3)=O)C=C2)=NC=N1

AST-487 (CAT: I004374) is a potent N,N’-diphenylurea-based competitive inhibitor of FLT3 with a Ki value of 0.12 μM. This compound demonstrates broad-spectrum activity, also inhibiting RET, KDR, c-KIT, and c-ABL kinases, all with IC50 values below 1 μM. By targeting these kinases, AST-487 is instrumental in cancer research, particularly for studying oncogenic signaling pathways involved in leukemia, thyroid carcinoma, and other malignancies. Its ability to modulate multiple kinase activities supports investigations into tumor progression, resistance mechanisms, and the development of kinase-targeted therapies, making it a valuable tool in drug discovery and therapeutic research.