AST5902 trimesylate

• CAT Number: I047173
• CAS Number: 2412155-74-7
• Molecular Formula: C30H41F3N8O11S3
• Molecular Weight: 842.88
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CNCCN(C)C1=NC(=C(NC2=NC=CC(=N2)C3=C[N](C)C4=C3C=CC=C4)C=C1NC(=O)C=C)OCC(F)(F)F.C[S](O)(=O)=O.C[S](O)(=O)=O.C[S](O)(=O)=O

AST5902 is the principal metabolite of alflutinib both in vitro and in vivo, which exerts remarkable antineoplastic activity similar to alflutinib. AST5902 exhibits much weak CYP3A4 induction potential compared to alflutinib.

Reference

[1] Xiao-Yun Liu, et al. Acta Pharmacol Sin. 2020 Oct;41(10):1366-1376.