Asterric Acid

• CAT Number: R001817
• CAS Number: 577-64-0
• Molecular Formula: C17H16O8
• Molecular Weight: 348.307
• Purity: 99%
• Synonyms: 2-(2-carboxy-3-hydroxy-5-methylphenoxy)-5-hydroxy-3-methoxy-benzoic acid, 1-methyl ester
• Target: ETA Receptors
• Solubility: Soluble in DMSO
• Appearance: White solid
• Storage: -20°C
• Analysis method: HPLC
• IUPAC Name: 2-hydroxy-6-(4-hydroxy-2-methoxy-6-methoxycarbonylphenoxy)-4-methylbenzoic acid
• InChI: InChI=1S/C17H16O8/c1-8-4-11(19)14(16(20)21)12(5-8)25-15-10(17(22)24-3)6-9(18)7-13(15)23-2/h4-7,18-19H,1-3H3,(H,20,21)
• InChIKey: XOKVHFNTYHPEHN-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(C(=C1)OC2=C(C=C(C=C2C(=O)OC)O)OC)C(=O)O)O

Asterric acid(cas 577-64-0) is a fungal metabolite with anti-angiogenic properties, isolated from a number of Aspergillus and Penicillium
species. It is an inhibitor of vascular endothelial growth factor (VEGF), inhibiting VEGF-induced tube formation of human
umbilical vein endothelial cells.

Reference

Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs. Lee H.J. et al. , J. Antibiot. 2002, 55, 552.

Asterric acid, a new endothelin binding inhibitor. Ohashi H. et al. , J. Antibiot. 1992, 45, 1684. 

Studies in the biochemistry of micro-organisms. 115. Metabolites of Penicillium frequentans Westling: isolation of sulochrin, asterric acid, (+)-bisdechlorogeodin and two new substituted anthraquinones, questin and questinol. Mahmoodian A. et al. , Biochem. J. 1964, 92, 369.